Hair necessities: Hair cell differentiation and regeneration

Mammalian vestibular hair cell regeneration.

Editorial: Sensory Hair Cell Death and Regeneration

Sensory hair cells are specializedmechanosensory receptors found in vertebrate auditory, vestibular and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Sensorineural hearing loss typically occurs when hair cells are damaged from infection, noise exposure, drugs (called ototoxins), and age-related decline. Unfortunately, as hair cell ...

Current concepts in hair cell regeneration.

Hair cell regeneration following various mechanical or chemical insults to the inner ear has become the subject of intense scientific research. This article details current concepts relating to this topic, including descriptions of the hair cell precursor population, the ultrastructural properties of the newly regenerated hair cells, and regeneration of hair cells on the vestibular epithelium. ...

Delta1 expression during avian hair cell regeneration.

Postembryonic production of hair cells, the highly specialized receptors for hearing, balance and motion detection, occurs in a precisely controlled manner in select species, including avians. Notch1, Delta1 and Serrate1 mediate cell specification in several tissues and species. We examined expression of the chicken homologs of these genes in the normal and drug-damaged chick inner ear to deter...

Mitochondrial aerobic respiration is activated during hair follicle stem cell differentiation, and its dysfunction retards hair regeneration

Background. Emerging research revealed the essential role of mitochondria in regulating stem/progenitor cell differentiation of neural progenitor cells, mesenchymal stem cells and other stem cells through reactive oxygen species (ROS), Notch or other signaling pathway. Inhibition of mitochondrial protein synthesis results in hair loss upon injury. However, alteration of mitochondrial morphology...